1339. Stereotactic laser ablation for subependymal giant cell astrocytomas: case series

Authors: Virendra R. Desai, MD; Virendra Desai, MD; Amanda Jenson, MD; Eric Hoverson; Mark Lee, MD (Houston, TX)

Introduction:

Subependymal giant cell astrocytomas (SEGAs) are rare tumors typically found in tuberous sclerosis patients. They typically grow in the region of the foramen of Monro and can occlude it, leading to hydrocephalus. Currently, gross total resection is the standard of care, with low rates of recurrence but high rates of complication, especially with larger lesions. Laser interstitial thermal therapy (LITT) is newly emerging treatment modality for a variety of pathologies. Here we present a case series of SEGAs managed via LITT and septostomy.

Methods:

A retrospective chart review was performed to identify three cases in which SEGAs were treated via LITT and septostomy.

Results:

Average age at surgery was 8.2 years. Pre-operative tumor volumes were 0.43, 1.51 and 3.88 cm3. Post-operative tumor volumes were 0.25, 0.21 and 0.68 cm3. Mean tumor volume reduction was 70%. No complications occurred. 

Conclusion:

LITT with septostomy should be considered a viable primary or adjunct treatment modality for SEGAs.