1305. Foramen Size as a Potential Risk Factor for Febrile Seizure Development in the Pediatric Population

Authors: Peyton D. Presto; Keith Hanson, BA; Mark Stephens, MBA; Nikki Tangella, MBA; Benjamin Elberson, PhD; Preston D'Souza, BS (Lubbock, TX)

Introduction:

Febrile seizures have been shown to occur in 2-5% of children between the ages of 6 months to 5 years, making them the most common seizures of childhood. However, no investigation has been conducted to explore foramen size and associated venous drainage as a potential risk factor for experiencing febrile seizures. Of particular interest are the parietal foramen, which conducts the parietal emissary vein, and the condylar canal, which conducts the occipital emissary vein. Emissary veins lack valves, which allows them to play a crucial role in selective brain cooling via a bidirectional flow of cooler blood from the head’s evaporating surface. If the cranial apertures conducting these veins are narrowed, the cerebral venous outflow is potentially reduced and therefore unable to cool the brain as rapidly as expected, leading to a febrile seizure.

Methods:

Here we conduct a retrospective chart review of all febrile seizure patient cases in Lubbock, TX, over the past 7 years. The patient’s head circumference percentile is documented and foramen and condylar canal dimensions are measured on prior head images. Both measures are classified as within, below, or above normal range and compared to our contrast group not experiencing febrile seizures. A chi-square analysis is used to determine if the below normal range percentage is higher than expected on each measure. 

Results:

We expect to compute the correlation between foramen size and a febrile seizure diagnosis. Ratios of head circumference to foramen and canal areas will also be calculated to account for variation in developmental stages in our patient population. Differences between groups in demographics and known risk factors for febrile seizure development will be assessed.

Conclusion:

Our findings will help guide further work in the detection and prevention of febrile seizures.