1389. Gender Impact on In-Hospital Mortality of Central Nervous System Cancers in the United States

Authors: Sheetal Hegde; Lauren Russell; Chelsea Mendonca; Mehdi Siddiqui; Miren Pena; Ali Seifi (San Antonio, TX)


Brain and other central nervous system (CNS) cancers are important causes of morbidity and mortality in American adults and children. Biological sex is one of many variables currently investigated for its influence on incidence and outcomes in CNS cancers. In this study, we aimed to examine the effect of gender differences on in-hospital mortality rates in central nervous system cancer patients in the United States.


Using the Healthcare Cost and Utilization Project (HCUP) database, data was queried from 2009-2014 for patients with CNS cancers in the United States. Z-tests were performed to evaluate differences in mortality rates by year and by sex.


The number of in-hospital deaths from CNS cancers between 2009 and 2014 was significantly greater in males than females (p<0.05) for all years except 2009 and 2012. The number of total in-hospital deaths during the study period significantly decreased from 1288 to 1020 (p<0.05) and the number of female in-hospital deaths significantly decreased from 577 to 370 (p<0.01). However, the number of male in-hospitals deaths did not change significantly (from 711 to 650, p=0.5). Moreover, during the study period, the total number of male in-hospital deaths (4115) was significantly greater than the total number of female in-hospital deaths (2932) (p<0.001).


These results show significantly greater in-hospital mortality in male patients with central nervous system cancer. Further prospective research is needed to uncover the reasons why the CNS cancer mortality rate is higher in men than in women.