1084. Epidemiological Analysis of 1404 Patients With Intracranial Aneurysm Followed in a Single Brazilian Institution

Authors: João Paulo Mota Telles; Jefferson Júnior, MD, PhD; Saul da Silva, MD; Ricardo Iglesio, MD; José Guilherme Caldas, MD, PhD; Manoel Teixeira, MD, PhD; Eberval Figueiredo, MD, PhD (Sao Paulo, Brazil)

Introduction: Several epidemiological studies evaluated the prevalence of intracranial aneurysms. Although geographic location is an important factor for intracranial aneurysm, few studies on the subject are carried out in Latin America. We aimed to evaluate the epidemiology of intracranial aneurysms in relation to location, gender, age, presence of multiple aneurysms and comorbidities in the Brazilian population. Methods: We performed a prospective analysis of 1404 patients diagnosed with intracranial aneurysm admitted to the Hospital das Clinicas of the University of Sao Paulo, a referral hospital for treatment of cerebrovascular diseases in Brazil. Patients admitted between September 2009 and August 2018 with diagnosis of intracranial aneurysm confirmed by digital subtraction angiography were included in the study. Results: A total of 2251 aneurysms were diagnosed. Females accounted for 1090 aneurysms (77.6%) and the mean age was 55.9 years (ranging 15-88). The most common location was middle cerebral artery (MCA) with 593 aneurysms (26.3%), followed by anterior cerebral artery (ACA) with 417 (18.5%), and internal carotid artery in the posterior communicating segment with 405 (18.0%) aneurysms. Males had higher rates of ACA (29.7%) while females had higher rates of MCA (26.1%) aneurysms. Sorting by size, 492 (21.8%) aneurysms were < 5mm, 1524 (67.7%) measured 5-10mm, 119 (5.3%) were 11-24mm, and 116 (5.2%) were > 24mm. A higher number of aneurysms per patient was associated with female gender (p<0.001) and smoking (p<0.001), but not with hypertension (p=0.121). Conclusion: The occurrence of intracranial aneurysms is related to several factors, including the geographical location. Our study showed important characteristics of a large number of Latin American patients regarding risk factors, location, size and number of intracranial aneurysms.