1025. Analysis of Vitamin D Levels in Vasospasm and Non-vasospasm sSAH patients

Authors: Samuel Kwabena Asante, MD; Jonathan Lee, MD; Vitaly Davidov, BS; Zoulficar Kobeissi, MD (Houston, TX)

Introduction: It is known that subarachnoid hemorrhage (spontaneous/aneurysmal) continues to cause significant morbidity and mortality. There is still ongoing research on the risk factors, as well as the factors that may influence the disease process. Data recently published have reported a link between low vitamin D levels to multiple vascular diseases, including cardiovascular and cerebrovascular (Park et al., 2015). Serum concentration of Vitamin D level is said to be acceptable at >30 ng/dl, deficient at ≤ 20 ng/dl and insufficient 21-29 ng/dl. Methods: We perform a single center retrospective analysis of patients who were admitted with spontaneous subarachnoid hemorrhage (sSAH) from January 2013 to May 2016. Patient records were reviewed to determine patient demographics. All patients who had a 25-Hydroxy Vitamin D levels recorded were separately analyzed. Vasospasm status was either diagnosed by cerebral angiogram or by Transcranial Doppler. Results: The average Vitamin D levels patient with angiographic or doppler (TCD) evidence of vasospasm was 21.79 compared to 23.20 in non-vasospasm patients. The percentage of vasospasm patient with optimum Vitamin D was 17% which was the same as that of non-vasospasm group. However, the percentage of vasospasm patient considered to be Vitamin D deficient was 42% compared to 62% in non-vasospasm group. Conclusion: Although some research have linked vitamin D levels to multiple vascular diseases, when comparing Vitamin D levels in patient with vasospasm to non-vasospasm group there were no significant difference. When the rate of Vitamin D deficiency was analyzed however, there was lower rate of Vitamin D deficiency in the vasospasm group than the non-vasospasm group. When the two groups were stratified by age, Hunt & Hess and Fisher score there was no significant difference in the two groups. Overall, there is no significant difference in Vitamin D levels in sSAH patient with vasospasm and those without vasospasm.