062. Gamma Knife Radiosurgery as an efficacious treatment for Pediatric Central Nervous System Tumors: A Retrospective Study of 99 NEOPLASMS.

Authors: Bhavya Pahwa

Brain tumors have an incidence of 1.15 to 5.14 cases per 100,000 children. These are treated with an aggressive course of chemotherapy, radiation and surgery. However, they are associated with a certain amount of morbidity. Radiosurgery has become a promising approach to manage these pediatric CNS tumors. The aim of the present study was to analyse the efficacy of radiosurgery in the treatment of a variety of pediatric tumors.Methods: 311 pediatric patients (? 18 years of age) were treated with gamma knife radiosurgery (GKRS) between 1997 and January 2012. Out of these 76 patients were treated for CNS tumors and hence included in this study. Patients treated for any other lesions were excluded. The patient's data was retrospectively analysed .
The mean age of the study group was 16 years. 32 patients received primary GKRS, 40 patients received secondary and 4 patients received both. A total of 99 NEOPLASMS were treated suggesting multiple NEOPLASMS in various patients. The mean tumor volume was 3.5 cm3 (0.14 - 123 cm3). The mean marginal dose was 12 Gy (11 – 35 Gy) and the mean tumour volume receiving marginal dose was 92%. The majority of the tumors were Acoustic Schwannoma (n=28) and Meningioma (n=27). 56 patients were available for proper follow up of which 40 experienced a reduction or stability in tumor size while 16 had a progression.
GKRS has the potential to become an indispensable tool in the management of pediatric brain NEOPLASMS.